A patient is 34 years old and concerned about possibly being a carrier for HNPCC because his father died of

A patient is 34 years old and concerned about possibly being a carrier for HNPCC because his father died of colon cancer at 39, his father’s sister died of colon cancer at age 41, and his brother (aged 37) now has colon cancer. The brother’s testing is negative for all the known mutations associated with inherited forms of colon cancer. How should this patient be counseled about his risk for colon cancer?
A)Explain that because the brother with cancer is negative for these gene mutations, this cancer is most likely sporadic, and his risk is the same as that for the general population.
B)Explain that he could benefit from testing even though his brother is negative for these mutations because reduced penetrance might account for his negative status.
C)Explain that testing for him would be of no benefit because of the current test limitations but that his family history does place him at high risk.
D)Explain that his risk is not related to his brother’s diagnosis because he did not inherit any genes from him, but because his father is a first-degree relative, testing should be considered.


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