When epidermal growth factor (EGF)—the ligand for the epidermal growth factor receptor (EGFR)—binds EGFR on the cell surface, the intracellular domain of the receptor changes shape into an “active state.” The receptor then induces a cascade of kinases in the cytoplasm, resulting in the activation of mitogen-activated protein kinase (MAPK). One effect of EGFR signaling is the stimulation of cell proliferation. Overactive EGFR is frequently found in cancer cells.
One strategy for developing anticancer drugs is to target the overactive signaling proteins found in cancer cells. Antibodies are proteins made by immune cells that only recognize specific biomolecules, called antigens. The major component of an anticancer drug is an antibody that specifically recognizes and binds EGFR.
Which of the following will most likely happen when this anticancer drug is applied to a tumor that has a high level of EGFR?
A. Tumor cells with active EGFR will increase and MAPK activity in the tumor will increase.
B. Tumor cells with active EGFR will decrease and MAPK activity in the tumor will increase.
C. Tumor cells with active EGFR will increase and MAPK activity in the tumor will decrease.
D. Tumor cells with active EGFR will decrease and MAPK activity in the tumor will decrease.
8) The price of a gallon of gasoline is increasing by 1¢ per week. If the price is $3.08 per gallon today,
what will it be in ten weeks?
A) Linear; $3.18
B) Exponential; $3.11
C) Exponential; $3.40
D) Linear; $3.17
1. Describe the impromptu speech. What are its major features?
2. What makes the Impromptu a challenging task?
3. What is the speaker’s Impromptu subject?
4. Define “impromptu”.
5. How does the Impromptu compare with the other speeches?
“The headdresses worn by Mayan kings, lords, and warriors were among the most elaborate status symbols ever devised. Concocted of exotic items [taken] from around the region—including parrot and macaw feathers, jaguar pelts, seashells, and jade—they told of men who received reverent tribute from those who depended on their [ability]. Indeed, the headdresses of commanding figures often bore the features of a god, from whose gaping mouth the mortal’s face would emerge. Such crowns reflected the Mayan conviction that on ceremonial occasions their leaders became one with the gods.”
—Empires Besieged, Time Frame A.D. 200–600
Mayans believed that on certain ceremonial occasions
their leaders were killed by the gods.
their leaders danced with the gods.
their leaders became one with the gods.
their leaders’ heads were deformed.
hurry im timed
The sequence -1/4, 2/5, -3/6, 4/7 is given.
Write an explicit equation to represent the sequence.
The radius of a circle is 1 kilometer. What is the area of a sector bounded by a 90° arc?
Give the exact answer in simplest form.
What suggestions or advice does de Medici give his son regarding clothing,
fumishings in his home, and punctuality?
Which factors led to World War I? Check all that apply.
can i get
expansion of empires
extreme national pride
influence by military leaders
revolt to gain independence
disputes over control of natural resources
attempts to stop the spread of an evil leader
Sheronda travels around the world for her job. She traveled 1,356 miles last year. This year, her plans will require her to travel 18 times as many miles as last year. How many miles will Sheronda travel this year?
If a particle with a charge of +3.3 × 10−18 C is attracted to another particle by a force of 2.5 × 10−8 N, what is the magnitude of the electric field at this location?
A 8.3 × 10−26 NC
B 1.8 × 1010 NC
C 1.3 × 10−10 N/C
D 7.6 × 109 N/C